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Article

An ALS-associated mutation in the FUS 3'-UTR disrupts a microRNA-FUS regulatory circuitry.

Nature communications - 9 Jul 2014

Dini Modigliani Stefano, Morlando Mariangela, Errichelli Lorenzo, Sabatelli Mario, Bozzoni Irene

Abstract excerpt

While the physiologic functions of the RNA-binding protein FUS still await thorough characterization, the pathonegetic role of FUS mutations in amyotrophic lateral sclerosis (ALS) is clearly established. Here we find that a human FUS mutation that leads to increased protein expression, and was identified in two ALS patients with severe outcome, maps to the seed sequence recognized by miR-141 and miR-200a in the...

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Share to 3' Untranslated Regions
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25004804
DOI: 10.1038/ncomms5335

Genes

FUS

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An ALS-associated mutation in the FUS 3'-UTR disrupts a microRNA-FUS regulatory circuitry.PMID 25004804Read ↗

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Mutations in the 3' untranslated region of FUS causing FUS overexpression are associated with amyotrophic lateral sclerosis.Semantic proximity Read ↗

Characterization of FUS mutations in amyotrophic lateral sclerosis using RNA-Seq.Semantic proximity Read ↗

Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3'UTR binding.Semantic proximity Read ↗

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Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

<i>FUS</i> ALS-causative mutations impact <i>FUS</i> autoregulation and the processing of RNA-binding proteins through intron retentionSemantic proximity Read ↗

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