Article

FUS Mislocalization Rewires a Cortical Gene Network to Drive Cognitive and Behavioral Impairment in ALS

2025-06-17

Abstract excerpt

<h4>Summary</h4> Cognitive and behavioral impairment affects up to half of individuals with amyotrophic lateral sclerosis (ALS), but their molecular origin remains unresolved. Here, we identify mislocalization of the RNA-binding protein FUS in cortical neurons as a defining feature in ALS patients with cognitive impairment (ALS-ci). Selective mislocalization of FUS in adult cortical projection neurons in mice is s...

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Literature Corpus work: 3ced3bf2-bb7b-5e29-925a-b3e554112a4d
DOI: 10.1101/2025.06.16.25329673

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