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Article

Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3'UTR binding.

Scientific reports - 16 Jul 2020

Garone Maria Giovanna, Alfano Vincenzo, Salvatori Beatrice, Braccia Clarissa, Peruzzi Giovanna, Colantoni Alessio, Bozzoni Irene, Armirotti Andrea, Rosa Alessandro

Abstract excerpt

Increasing evidence suggests that in Amyotrophic Lateral Sclerosis (ALS) mutated RNA binding proteins acquire aberrant functions, leading to altered RNA metabolism with significant impact on encoded protein levels. Here, by taking advantage of a human induced pluripotent stem cell-based model, we aimed to gain insights on the impact of ALS mutant FUS on the motoneuron proteome. Label-free proteomics analysis by...

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Identifiers

PMID: 32678235
DOI: 10.1038/s41598-020-68794-6
PMCID: PMC7366621

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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