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Article

FUS Mutant Human Motoneurons Display Altered Transcriptome and microRNA Pathways with Implications for ALS Pathogenesis.

Stem cell reports - 14 Nov 2017

De Santis Riccardo, Santini Laura, Colantoni Alessio, Peruzzi Giovanna, de Turris Valeria, Alfano Vincenzo, Bozzoni Irene, Rosa Alessandro

Abstract excerpt

The FUS gene has been linked to amyotrophic lateral sclerosis (ALS). FUS is a ubiquitous RNA-binding protein, and the mechanisms leading to selective motoneuron loss downstream of ALS-linked mutations are largely unknown. We report the transcriptome analysis of human purified motoneurons, obtained from FUS wild-type or mutant isogenic induced pluripotent stem cells (iPSCs). Gene ontology analysis of...

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Source

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Identifiers

PMID: 28988989
DOI: 10.1016/j.stemcr.2017.09.004
PMCID: PMC5830977

Genes

FUS
ELAVL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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