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Article

A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons.

Molecular neurobiology - 1 Oct 2018

Capauto Davide, Colantoni Alessio, Lu Lei, Santini Tiziana, Peruzzi Giovanna, Biscarini Silvia, Morlando Mariangela, Shneider Neil A, Caffarelli Elisa, Laneve Pietro, Bozzoni Irene

Abstract excerpt

Mutations in fused in sarcoma (FUS) cause amyotrophic lateral sclerosis (ALS). FUS is a multifunctional protein involved in the biogenesis and activity of several types of RNAs, and its role in the pathogenesis of ALS may involve both direct effects of disease-associated mutations through gain- and loss-of-function mechanisms and indirect effects due to the cross talk between different classes of FUS-dependent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29430619
DOI: 10.1007/s12035-018-0884-4
PMCID: PMC6132778

Genes

FUS

Variants

Provenance

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A Regulatory Circuitry Between Gria2, miR-409, and miR-495 Is Affected by ALS FUS Mutation in ESC-Derived Motor Neurons.PMID 29430619Read ↗

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