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Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways

10 May 2016

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment available. An increasing number of genetic causes of ALS are being identified, but how these genetic defects lead to motor neuron degeneration and to which extent they affect common cellular pathways remains incompletely understood. To address these questions, we performed an interactomic analysis to identify...

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PMID: 27164932
DOI: 10.1007/s00401-016-1575-8

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