Back to search

Article

Prioritizing protein targets for dyslipidaemia and cardiovascular diseases using Mendelian randomization in South Asians

2024-12-19

Abstract excerpt

South Asians are at higher risk of dyslipidaemia-a modifiable risk factor for cardiovascular diseases (CVDs). We aimed to identify protein targets for dyslipidaemia and CVDs in this population. We used a two-sample Mendelian randomization (MR) approach, supplemented with MR-Egger, weighted median, colocalization, and generalized MR (GMR), to evaluate the effect of 2,800 plasma proteins on high/low/non-high-density...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b8d90eb0-4fd9-58a6-af49-b50695a91485
DOI
10.1101/2024.12.18.24319223
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Prioritizing protein targets for dyslipidaemia and cardiovascular diseases using Mendelian randomization in South AsiansDOI 10.1101/2024.12.18.24319223
Cross-population proteome-wide mendelian randomization study identifies likely causal proteins for cardiovascular diseases.Semantic proximity
Therapeutic protein targets for cardiometabolic diseases: Mendelian randomization integrating plasma proteomes with genome-wide association dataSemantic proximity
Genomic atlas of 7,000 plasma proteins and their associations with diseases and traits in East Asian populationsSemantic proximity
Lipids, Blood Pressure, and Diabetes Mellitus on Risk of Cardiovascular Diseases in East Asians: A Mendelian Randomization StudySemantic proximity
Proteome-wide Mendelian randomization identifies candidate causal proteins for cardiovascular diseasesSemantic proximity
Comparing the effect profile of CETP in individuals of East Asian and European ancestriesSemantic proximity
Mendelian Randomization and Bayesian Colocalization Analysis Implicate Glycoprotein VI as a Potential Drug Target for Cardioembolic Stroke in South Asian Populations.Semantic proximity
Proteome-wide Mendelian randomization identifies potential therapeutic targets for nonalcoholic fatty liver diseases.Semantic proximity
Unraveling the influence of body mass index on complex diseases in East Asians: Insights from Mendelian randomization phenome-wide association study.Semantic proximity
Exploring Potential Drug Targets in Multiple Cardiovascular Diseases: A Study Based on Proteome‐Wide Mendelian Randomization and Colocalization AnalysisSemantic proximity
Comprehensive mendelian randomization analysis of plasma proteomics to identify new therapeutic targets for the treatment of coronary heart disease and myocardial infarctionSemantic proximity
Genome-wide analysis of blood lipid metabolites in over 5,000 South Asians reveals biological insights at cardiometabolic disease lociSemantic proximity
Select a neighboring publication to make it the new centre.