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Article

Mendelian Randomization and Bayesian Colocalization Analysis Implicate Glycoprotein VI as a Potential Drug Target for Cardioembolic Stroke in South Asian Populations.

Journal of the American Heart Association - 20 Aug 2024

Wu Siwei, Meena Devendra, Yarmolinsky James, Gill Dipender, Smith Alexander, Dib Marie-Joe, Chauhan Ganesh, Rohatgi Anand, Dehghan Abbas, Tzoulaki Ioanna

Abstract excerpt

BACKGROUND: Circulating plasma proteins are clinically useful biomarkers for stroke risk. We examined the causal links between plasma proteins and stroke risk in individuals of South Asian ancestry. METHODS AND RESULTS: We applied proteome-wide Mendelian randomization and colocalization approaches to understand causality of 2922 plasma proteins on stroke risk in individuals of South Asian ancestry. We obtained...

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PMID: 39119976
DOI: 10.1161/JAHA.124.035008
PMCID: PMC11963915

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