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Exploring T-cell metabolism in tuberculosis: development of a diagnostic model using metabolic genes

16 Jun 2025

Abstract excerpt

OBJECTIVES: The early diagnosis and immunoregulatory mechanisms of active tuberculosis (ATB) and latent tuberculosis infection (LTBI) remain unclear, and the role of metabolic genes in host-pathogen interactions requires further investigation. METHODS: Single-cell RNA sequencing (scRNA-seq) was applied to analyze peripheral blood mononuclear cells (PBMCs) from 7 individuals, including 2 healthy controls (HC), 2...

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PMID: 40524207
DOI: 10.1186/s40001-025-02768-0

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