Article

Deletion of class II ARF causes essential tremors through Nav1.6 traffic impairment

2018-06-27

Abstract excerpt

ADP-ribosylation factors (ARFs) are a family of small monomeric GTPases consisting of three classes. In the present study, we generated class II ARF-deficient mice (ARF4 +/− /ARF5 −/− ) and found that they exhibited severe movement-associated tremors. Treatment of the mice with propranolol and gabapentin, which alleviate symptoms in patients with essential tremors, similarly reduced the amplitude of the patholog...

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Literature Corpus work: b8b17d14-cf23-5b86-9903-22ac20a02a47
DOI: 10.1101/357160

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