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Article

Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion.

Developmental biology - 1 Oct 2008

Nekrasova Tanya, Jobes Michelle L, Ting Jenhao H, Wagner George C, Minden Audrey

Abstract excerpt

PAK6 is a member of the group B family of PAK serine/threonine kinases, and is highly expressed in the brain. The group B PAKs, including PAK4, PAK5, and PAK6, were first identified as effector proteins for the Rho GTPase Cdc42. They have important roles in filopodia formation, the extension of neurons, and cell survival. Pak4 knockout mice die in utero, and the embryos have several abnormalities, including a...

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Source

Identifiers

PMID: 18675265
DOI: 10.1016/j.ydbio.2008.07.006

Genes

PAK6
PAK4
PAK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion.PMID 18675265Read ↗

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p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD.Semantic proximity Read ↗

Second occurrence of the PAK3-R67C variation and multiscale analysis of the corresponding knock-in mice reveal novel phenotypic features and functional synaptic defects.Semantic proximity Read ↗

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The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway.Semantic proximity Read ↗

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