Article

Cerebellar Purkinje cell microcircuits are essential for tremor

2019-09-15

Abstract excerpt

Tremor is currently ranked as the most common movement disorder. The brain regions and neural signals that initiate the debilitating shakiness of different body parts remain unclear. Here, we found that genetically silencing cerebellar Purkinje cell activity blocked tremor in mice that were given the tremorgenic drug harmaline. We show in awake behaving mice that the onset of tremor is coincident with rhythmic Pur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0d0d8771-e8ad-537d-9cdc-504e55c9b0d5
DOI: 10.1101/770321

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cerebellar Purkinje cell microcircuits are essential for tremorDOI 10.1101/770321Read

Cerebellar Dysfunction as a Source of Dystonic Phenotypes in MiceSemantic proximity Read

Cerebellar nuclei cells produce distinct pathogenic spike signatures in mouse models of ataxia, dystonia, and tremorSemantic proximity Read

Circuitry dynamics of the cerebellum inform differential therapeutic responses and patient stratification in essential tremorSemantic proximity Read

Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in miceSemantic proximity Read

Cerebellar deep brain stimulation as a dual-function therapeutic for restoring movement and sleep in dystonic miceSemantic proximity Read

PRRT2-dependent dyskinesia: cerebellar, paroxysmal and persistent.Semantic proximity Read

PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum.Semantic proximity Read

Functional Analysis of Distinct Populations of Subthalamic Nucleus Neurons on Parkinson’s Disease and OCD-like Behaviors in MiceSemantic proximity Read

EMG analysis of harmaline-induced tremor in normal and three strains of mutant mice with Purkinje cell degeneration and the role of the inferior olive.Semantic proximity Read

Role of Synchronous Activation of Cerebellar Purkinje Cell Ensembles in Multi-joint Movement Control.Semantic proximity Read

Abnormal cerebellar function and tremor in a mouse model for non‐manifesting partially penetrant dystonia type 6Semantic proximity Read

Human and mouse cerebellar inhibitory circuits in dystonic crisis and their modulation with therapeutic stimulationSemantic proximity Read