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Article

Genetic essential tremor in γ-aminobutyric acidA receptor α1 subunit knockout mice

1 Mar 2005

Abstract excerpt

Essential tremor is the most common movement disorder and has an unknown etiology. Here we report that gamma-aminobutyric acidA (GABA(A)) receptor alpha1-/- mice exhibit postural and kinetic tremor and motor incoordination that is characteristic of essential tremor disease. We tested mice with essential-like tremor using current drug therapies that alleviate symptoms in essential tremor patients (primidone,...

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PMID: 15765150
DOI: 10.1172/jci23625

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