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Article

Arf6-GEF BRAG1 regulates JNK-mediated synaptic removal of GluA1-containing AMPA receptors: a new mechanism for nonsyndromic X-linked mental disorder.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Aug 2012

Myers Kenneth R, Wang Guangfu, Sheng Yanghui, Conger Kathryn K, Casanova James E, Zhu J Julius

Abstract excerpt

Activity-dependent modifications of excitatory synapses contribute to synaptic maturation and plasticity, and are critical for learning and memory. Consequently, impairments in synapse formation or synaptic transmission are thought to be responsible for several types of mental disabilities. BRAG1 is a guanine nucleotide exchange factor for the small GTP-binding protein Arf6 that localizes to the postsynaptic...

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Identifiers

PMID: 22915114
DOI: 10.1523/JNEUROSCI.1942-12.2012
PMCID: PMC3459061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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