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Article

Genetic variation in the glymphatic pathway predicts cognition and neurodegeneration in preclinical Alzheimer's disease

2026-05-06

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Impaired glymphatic clearance has been implicated in Alzheimer’s disease (AD) through reduced clearance of amyloid-β (Aβ) and other metabolites from the brain. Mislocalisation of aquaporin-4 (AQP4), a water channel protein anchored to astrocytic endfeet by the dystrophin-associated complex (DAC), has been linked to increased Aβ accumulation, neurodegeneration...

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Literature Corpus work
b8a74e6d-b5ed-57f2-8a60-14aa1d241350
DOI
10.21203/rs.3.rs-9444687/v1
Open publication

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