Article

Genetic Associations with Age at Dementia Onset in the<i>PSEN1 E280A</i>Colombian Kindred

2020-09-25

Abstract excerpt

<h4>INTRODUCTION</h4> Genetic associations with Alzheimer’s disease (AD) age at onset (AAO) could reveal genetic variants with therapeutic applications. We present a large Colombian kindred with autosomal dominant AD (ADAD) as a unique opportunity to discover AAO genetic associations. <h4>METHODS</h4> A genetic association study was conducted for ADAD dementia AAO in 340 individuals with the PSEN1 E280A mutation v...

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Literature Corpus work: 67eb6a6a-624f-5fee-96e6-5a63161ee5bd
DOI: 10.1101/2020.09.23.20198424

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