Article
Association Between Single Nucleotide Polymorphisms in the Aquaporin-4 Gene and Longitudinal Changes in White Matter Free Water and Cognitive Function in Non-Demented Older Adults.
Human brain mapping - 1 Mar 2025
Liu Lingyun, Zeng Qingze, Luo Xiao, Hong Hui, Fang Yi, Xie Linyun, Zhang Yao, Lin Miao, Wang Shuyue, Li Kaicheng, Liu Xiaocao, Zhang Ruiting, Chen Yanxing, Yang Yunjun, Huang Peiyu
Abstract excerpt
We investigated whether aquaporin-4 (AQP4) single-nucleotide polymorphisms (SNPs) influence Alzheimer's disease (AD) progression through changes in the glymphatic system. We included 242 non-dementia participants and chose six SNPs previously shown to be related to AD. We analyzed the associations between AQP4 SNPs and glymphatic markers, including enlarged perivascular spaces (PVS), white matter free water (FW),...
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