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A spatially resolved genomic–molecular atlas of human white‑matter microstructure

2026-07-09

Abstract excerpt

Human white matter has been linked to inherited variation, circulating molecular state and brain disease, but these layers have rarely been mapped onto the same tract anatomy. Here we measured genetic effects along 6,090 atlas-aligned fiber pathways sampled at 609,000 locations in 72,185 UK Biobank participants, and integrated proteomic and metabolomic profiles within the same anatomical frame. Genetic effects wer...

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Literature Corpus work
ed51c53f-7596-53a2-ac11-bcdfbffa8219
DOI
10.64898/2026.07.06.26357381
Open publication

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A spatially resolved genomic–molecular atlas of human white‑matter microstructureDOI 10.64898/2026.07.06.26357381
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