Article

Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability

2026-02-20

Abstract excerpt

Aquaporin-4 (AQP4) water channels support the glymphatic system, a brain-wide pathway that clears cerebral waste products. Despite its importance, the whole-brain organization of this system in humans remains underexplored. Here we use AQP4 gene expression as a molecular anchor to reconstruct a whole-brain glymphatic-related topography and link it to vascular physiology, edema, and neurodegenerative vulnerability....

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Literature Corpus work: 74ec6273-7ae2-52f7-af3b-70879c76b6a7
DOI: 10.64898/2026.02.18.706679

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