Article
Shared genetic architecture between DTI-ALPS traits and neurodegenerative diseases.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2026
Zhou Hong, Deng Jialin, Wu Qian, Zeng Yule, Wang Tianyao, Wu Jiayi, Duan Xiaomei, Tang Beisha, Wei Xinhua, He Lu, Liu Feng
Abstract excerpt
INTRODUCTION: Diffusion tensor image analysis along the perivascular space (DTI-ALPS) index is associated with neurodegenerative diseases (NDDs), but its shared genetic basis with NDDs remains unclear. METHODS: By integrating genome-wide association datasets for three DTI-ALPS traits and seven NDDs, we quantified polygenic overlap using MiXeR, identified shared loci using conditional and conjunctional false...
Read the complete abstract on PubMedTopics
- Neurodegenerative Diseases
- Humans
- Genome-Wide Association Study
- Diffusion Tensor Imaging
- Multifactorial Inheritance