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Article

Inhibition of in vitro and in vivo brown fat differentiation program by myostatin.

Obesity (Silver Spring, Md.) - 1 Jun 2013

Braga Melissa, Pervin Shehla, Norris Keith, Bhasin Shalender, Singh Rajan

Abstract excerpt

OBJECTIVE: Obesity arises mainly due to the imbalance between energy storage and its expenditure. Metabolically active brown adipose tissue (BAT) has recently been detected in humans and has been proposed as a new target for anti-obesity therapy because of its unique capacity to regulate energy expenditure. Myostatin (Mst), a negative regulator of muscle mass, has been identified as a potential target to regulate...

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Topics

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Share to Adipose Tissue, Brown
Share to Body Composition
Share to Bone Morphogenetic Protein 7

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ion Channels

Share to Lipid Metabolism

Share to Myostatin

Share to Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Share to Uncoupling Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 23868854
DOI: 10.1002/oby.20117
PMCID: PMC3735638

Genes

PRDM16
UCP1
BMP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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