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miR-202 drives medaka fertility by targeting antagonistic Yap-dependent transcriptional regulators <i>tead3b</i> and <i>vgll4b</i> in a sex-dependent manner

2026-02-13

Abstract excerpt

How miRNAs can sometimes drive major organism-level phenotypes by targeting a single gene and by triggering limited changes in mRNA levels remains poorly understood, especially in vertebrates. In medaka, the knockout of miR-202-5p, a gonad-specific miRNA in vertebrates, leads to impaired male and female fertility, including drastically reduced egg production and low developmental success. Here we show that miR-202...

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Literature Corpus work
b83e55ee-2bac-5c24-905f-f05be8b6d2fa
DOI
10.64898/2026.02.12.705488
Open publication

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miR-202 drives medaka fertility by targeting antagonistic Yap-dependent transcriptional regulators <i>tead3b</i> and <i>vgll4b</i> in a sex-dependent mannerDOI 10.64898/2026.02.12.705488
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