Article

The pioneer factor Zelda induces male-to-female somatic sex reversal in adult tissues

2025-03-31

Abstract excerpt

<h4>Summary</h4> Somatic sex identity must be maintained throughout adulthood for tissue function. Adult somatic stem cells in the Drosophila testis (i.e., CySCs) lacking the transcription factor Chinmo are reprogrammed to their ovarian counterparts by induction of female-specific Tra F , but this is not mechanistically understood. Pioneer factors play central roles in direct reprogramming, and many upregulated...

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Literature Corpus work: 5b735120-4836-52bf-8ec9-e4d69ad50f8b
DOI: 10.1101/2025.03.26.645575

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