Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct production of XY(DMY-) sex reversal female medaka (Oryzias latipes) by embryo microinjection of TALENs.

Scientific reports - 14 Sept 2015

Luo Daji, Liu Yun, Chen Ji, Xia Xiaoqin, Cao Mengxi, Cheng Bin, Wang Xuejuan, Gong Wuming, Qiu Chao, Zhang Yunsheng, Cheng Christopher Hon Ki, Zhu Zuoyan, Hu Wei

Abstract excerpt

Medaka is an ideal model for sex determination and sex reversal, such as XY phenotypically female patients in humans. Here, we assembled improved TALENs targeting the DMY gene and generated XY(DMY-) mutants to investigate gonadal dysgenesis in medaka. DMY-TALENs resulted in indel mutations at the targeted loci (46.8%). DMY-nanos3UTR-TALENs induced mutations were passed through the germline to F1 generation with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Deoxyribonucleases
Share to Embryo, Nonmammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ Cells

Share to Gonads

Share to Microinjections

Share to Oryzias

Share to Sex Chromosomes

Share to Sex Determination Processes

Source

Open in PubMed Open full text

Identifiers

PMID: 26365677
DOI: 10.1038/srep14057
PMCID: PMC4568496

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct production of XY(DMY-) sex reversal female medaka (Oryzias latipes) by embryo microinjection of TALENs.PMID 26365677Read ↗

Dmy initiates masculinity by altering Gsdf/Sox9a2/Rspo1 expression in medaka (Oryzias latipes).Semantic proximity Read ↗

DMY is a Y-specific DM-domain gene required for male development in the medaka fish.Semantic proximity Read ↗

Wild-derived XY sex-reversal mutants in the Medaka, Oryzias latipes.Semantic proximity Read ↗

Dmrt1 mutation causes a male-to-female sex reversal after the sex determination by Dmy in the medaka.Semantic proximity Read ↗

The Y chromosome that lost the male-determining function behaves as an X chromosome in the medaka fish, Oryzias latipes.Semantic proximity Read ↗

miR-202 drives medaka fertility by targeting antagonistic Yap-dependent transcriptional regulators <i>tead3b</i> and <i>vgll4b</i> in a sex-dependent mannerSemantic proximity Read ↗

Identification of miR-187 as a modulator of early oogenesis and female fecundity in medakaSemantic proximity Read ↗

The pioneer factor Zelda induces male-to-female somatic sex reversal in adult tissuesSemantic proximity Read ↗

A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway.Semantic proximity Read ↗

Common Spontaneous Sex-Reversed XX males of the Medaka Oryzias latipesSemantic proximity Read ↗

Tudor-domain containing protein 5-like promotes male sexual identity in the Drosophila germline and is repressed in females by Sex lethalSemantic proximity Read ↗

A systematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.