Article
Looking for a needle in a haystack: de novo phenotypic target identification reveals Hippo pathway-mediated miR-202 regulation of egg production.
Nucleic acids research - 25 Jan 2024
Janati-Idrissi Sarah, de Abreu Mariana Roza, Guyomar Cervin, de Mello Fernanda, Nguyen Thaovi, Mechkouri Nazim, Gay Stéphanie, Montfort Jérôme, Gonzalez Anne Alicia, Abbasi Marzieh, Bugeon Jérôme, Thermes Violette, Seitz Hervé, Bobe Julien
Abstract excerpt
Understanding microRNA (miRNA) functions has been hampered by major difficulties in identifying their biological target(s). Currently, the main limitation is the lack of a suitable strategy to identify biologically relevant targets among a high number of putative targets. Here we provide a proof of concept of successful de novo (i.e. without prior knowledge of its identity) miRNA phenotypic target (i.e. target...
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