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Network Analysis and Human Single Cell Brain Transcriptomics Reveal Novel Aspects of Alpha-Synuclein (SNCA) Biology

2020-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Alpha-synuclein (SNCA) aggregates are pathological hallmarks of synucleinopathies, neurodegenerative disorders including Parkinson’s Disease (PD) and Lewy Body Dementia (LBD). Functional networks are not yet well-characterized for SNCA by CNS cell type. We investigated cell-specific differences in SNCA expression using Allen Brain Database single-nucleus RNA-seq data from human Middle Temporal G...

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Literature Corpus work: b8315b4a-1467-5255-9459-08e2736271b5
DOI: 10.1101/2020.06.05.137166

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