Article

Coordinated dysregulation of modular gene activity in human neuropathologies

2026-08-28

Abstract excerpt

Understanding which genes are reproducibly dysregulated in which cell types is foundational knowledge for efforts to slow or reverse pathologies. For neuropathologies, such efforts rely primarily on differential expression analysis of single-nucleus RNA-seq (snRNA-seq) data. However, this strategy suffers from experimental and statistical challenges that limit marker gene reproducibility. We describe a novel strat...

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Literature Corpus work: 9f024c36-676a-5638-8d2b-525db4580f91
DOI: 10.64898/2026.08.25.747130

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