Article

DNA damaged-induced phosphorylation of a viral replicative DNA helicase results in inhibition of DNA replication through attenuation of helicase function

2023-09-30

Abstract excerpt

<h4>ABSTRACT</h4> A major function of the DNA damage responses (DDRs) that act during the replicative phase of the cell cycle is to inhibit initiation and elongation of DNA replication. The polyomavirus SV40 is an important model system for studying human DNA replication and DDRs due to its heavy reliance on host factors for viral DNA replication, and the arrest of SV40 DNA replication in response to DDR activati...

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Literature Corpus work: b8234cc6-cc9b-53e9-9970-a702c356ca62
DOI: 10.1101/2023.09.29.560221

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