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Article

Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis.

Proceedings of the National Academy of Sciences of the United States of America - 5 May 2015

Ortega Janice, Li Jessie Y, Lee Sanghee, Tong Dan, Gu Liya, Li Guo-Min

Abstract excerpt

Proliferating cell nuclear antigen (PCNA) plays essential roles in eukaryotic cells during DNA replication, DNA mismatch repair (MMR), and other events at the replication fork. Earlier studies show that PCNA is regulated by posttranslational modifications, including phosphorylation of tyrosine 211 (Y211) by the epidermal growth factor receptor (EGFR). However, the functional significance of Y211-phosphorylated...

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Identifiers

PMID: 25825764
DOI: 10.1073/pnas.1417711112
PMCID: PMC4426468

Genes

PCNA
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation of PCNA by EGFR inhibits mismatch repair and promotes misincorporation during DNA synthesis.PMID 25825764Read ↗

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