Article

Inflammation induced T <sub>h</sub> 17 cells synergize with the inflammation-trained microbiota to mediate host-resiliency against intestinal injury

2024-03-28

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Aims</h4> Inflammation can generate pathogenic T h 17 cells and cause a inflammatory dysbiosis. In the context of Inflammatory Bowel Disease (IBD) these inflammatory T h 17 cells and dysbiotic microbiota may perpetuate injury to intestinal epithelial cells (IECs). However, many models of IBD like T-cell transfer colitis and IL-10 -/- mice rely on the absence of regulatory...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 81291d2b-f1a0-5107-9dce-1afba562bc1d
DOI: 10.1101/2024.03.25.586435

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inflammation induced T <sub>h</sub> 17 cells synergize with the inflammation-trained microbiota to mediate host-resiliency against intestinal injuryDOI 10.1101/2024.03.25.586435Read

Enteric infection priming confers IL-17A–dependent protection from chemically-induced ColitisSemantic proximity Read

c-Maf-dependent regulatory T cells mediate immunological tolerance to intestinal microbiotaSemantic proximity Read

Defined microbiota transplant restores Th17/RORγt <sup>+</sup> regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotasSemantic proximity Read

Intestinal inflammation reversibly alters the microbiota to drive susceptibility to <i>Clostridioides difficile</i> colonization in a mouse model of colitisSemantic proximity Read

Intestinal inflammation and altered gut microbiota associated with inflammatory bowel disease renders mice susceptible to <i>Clostridioides difficile</i> colonization and infectionSemantic proximity Read

A gut pathobiont synergizes with the microbiota to instigate inflammatory disease marked by immunoreactivity against other symbionts but not itselfSemantic proximity Read

MAIT cells drive chronic inflammation in a genetically diverse murine model of spontaneous colitisSemantic proximity Read

Pro-inflammatory Pathways Contribute to Pathogenesis of <i>Clostridioides difficile</i> Infection in a Murine Model - A Spatial Transcriptomics StudySemantic proximity Read

High-fat diet rewires gut host-microbiota relationship to derive worse outcomes following <i>Clostridioides difficile</i> infectionSemantic proximity Read

<i>Helicobacter hepaticus</i> as disease driver in a novel CD40-mediated model of colitisSemantic proximity Read

Fecal microbiota transplantation increases colonic IL-25 and dampens tissue inflammation in patients with recurrent<i>Clostridioides difficile</i>Semantic proximity Read

Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestineSemantic proximity Read