Article
Disrupted regulatory T cell homeostasis in inflammatory bowel diseases.
World journal of gastroenterology - 21 Jan 2016
Pedros Christophe, Duguet Fanny, Saoudi Abdelhadi, Chabod Marianne
Abstract excerpt
In the gut, where billions of non-self-antigens from the food and the microbiota are present, the immune response must be tightly regulated to ensure both host protection against pathogenic microorganisms and the absence of immune-related pathologies. It has been well documented that regulatory T cells (Tregs) play a pivotal role in this context. Indeed, Tregs are able to prevent excessive inflammation, which can...
Topics
- Animals
- Gastrointestinal Agents
- Gastrointestinal Microbiome
- Homeostasis
- Host-Pathogen Interactions
- Humans
- Immunosuppressive Agents
- Immunotherapy
- Inflammation Mediators
- Inflammatory Bowel Diseases
- Intestinal Mucosa