Article

Detailed Survey of an in-vitro Intestinal Epithelium Model by Single-Cell Transcriptomics

2023-05-23

Abstract excerpt

The gut plays a critical role in maintaining human health by facilitating the absorption of nutrients, regulating metabolism, and interacting with the immune system and gut microbiota. The co-culture of two human colorectal cancer cell lines, Caco-2 and HT29, on Transwell is commonly used as an in vitro gut mimic in studies of intestinal absorption pharmacokinetics, gut mechanics, and gut-microbe interplay given...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 428b4625-4c62-53a8-8b54-810c0b7044f4
DOI: 10.1101/2023.05.23.541940

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Detailed Survey of an in-vitro Intestinal Epithelium Model by Single-Cell TranscriptomicsDOI 10.1101/2023.05.23.541940Read

Detailed survey of an in vitro intestinal epithelium model by single-cell transcriptomicsSemantic proximity Read

Comprehensive gene expression analysis of organoid-derived healthy human colonic epithelium and cancer cell line by stimulated with live probiotic bacteriaSemantic proximity Read

Novel In Vitro Models for Cell Differentiation and Drug Transport Studies of the Human IntestineSemantic proximity Read

Transcriptome comparisons of in vitro intestinal epithelia grown under static and microfluidic gut-on-chip conditions with in vivo human epitheliaSemantic proximity Read

Single-cell transcriptomic mapping of intestinal epithelium that undergoes 3D morphogenesis and mechanodynamic stimulation in a gut-on-a-chipSemantic proximity Read

The in vitro intestinal cell model: different co-cultured cells create different applicationsSemantic proximity Read

The Progress of Intestinal Epithelial Models from Cell Lines to Gut-On-ChipSemantic proximity Read

In vitro Models of the Small Intestine for Studying Intestinal DiseasesSemantic proximity Read

Drivers of Transcriptional Variance in Human Intestinal Epithelial OrganoidsSemantic proximity Read

Human pluripotent stem cell-derived intestinal epithelial cells maintain small intestine-specific functions over time, even with repeated cell divisionSemantic proximity Read

Oleic Acid Uptake Reveals the Rescued Enterocyte Phenotype of Colon Cancer Caco-2 by HT29-MTX Cells in Co-Culture Mode.Semantic proximity Read

Intestine-on-chip enhances nutrient and drug metabolism and maturation of iPSC-derived intestinal epithelial cells relative to organoids and TranswellsSemantic proximity Read