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Article

Drivers of transcriptional variance in human intestinal epithelial organoids

6 Oct 2021

Abstract excerpt

Human intestinal epithelial organoids (enteroids and colonoids) are tissue cultures used for understanding the physiology of the human intestinal epithelium. Here, we explored the effect on the transcriptome of common variations in culture methods, including extracellular matrix substrate, format, tissue segment, differentiation status, and patient heterogeneity. RNA-sequencing datasets from 276 experiments...

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PMID: 34612061
DOI: 10.1152/physiolgenomics.00061.2021

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