Systematic evaluation of colorectal cancer organoid system by single-cell RNA-Seq analysis

Abstract excerpt

BACKGROUND: Patient-derived organoid culture is a powerful system for studying the molecular mechanisms of cancers, especially colorectal cancer (CRC), one of the most prevalent cancers worldwide. There are two main types of 3D culture methods for colonic cells, but the similarities and differences between gene expression patterns in different culture media remain largely unexplored. RESULTS: Here, we establish...

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