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Detailed survey of an in vitro intestinal epithelium model by single-cell transcriptomics

29 Feb 2024

Abstract excerpt

gut mimic, yet the translatability of insights from such a system to adult human physiological contexts is not fully characterized. Here, we used single-cell RNA sequencing on the co-culture to obtain a detailed survey of cell type heterogeneity in the system and conducted a holistic comparison with human physiology. We identified the intestinal stem cell-, transit amplifying-, enterocyte-, goblet cell-, and...

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PMID: 38523788
DOI: 10.1016/j.isci.2024.109383

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