Back to search

Article

Translation inhibition efficacy does not determine the <i>Plasmodium berghei</i> liver stage antiplasmodial efficacy of protein synthesis inhibitors

2023-12-07

Abstract excerpt

Protein synthesis is a core cellular process, necessary throughout the complex lifecycle of Plasmodium parasites, thus specific translation inhibitors would be a valuable class of antimalarial drugs, capable of both treating symptomatic infections in the blood and providing chemoprotection by targeting the initial parasite population in the liver, preventing both human disease and parasite transmission back to th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b7f8cf72-8245-5cf6-af07-00c8bedeb8d5
DOI
10.1101/2023.12.07.570699
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Translation inhibition efficacy does not determine the <i>Plasmodium berghei</i> liver stage antiplasmodial efficacy of protein synthesis inhibitorsDOI 10.1101/2023.12.07.570699
A high-throughput <i>in vitro</i> translation screen towards discovery of novel antimalarial protein translation inhibitorsSemantic proximity
Screening of a chemogenetic library unveils dual-stage antimalarials with low cytotoxicitySemantic proximity
Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagySemantic proximity
Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profilesSemantic proximity
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.Semantic proximity
High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent MalariaSemantic proximity
Identification of potent and selective <i>N</i> -myristoyltransferase inhibitors of <i>Plasmodium vivax</i> liver stage hypnozoites and schizontsSemantic proximity
Translational Control in Plasmodium and Toxoplasma ParasitesSemantic proximity
Long-term live imaging reveals cytosolic immune responses of host hepatocytes against <i>Plasmodium</i> infection and parasite escape mechanismsSemantic proximity
Disrupting Plasmodium UIS3–host LC3 interaction with a small molecule causes parasite elimination from host cellsSemantic proximity
A replication-competent late liver stage–attenuated human malaria parasiteSemantic proximity
Suppression of host p53 is critical for Plasmodium liver-stage infection.Semantic proximity
Select a neighboring publication to make it the new centre.