Article
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.
Science (New York, N.Y.) - 9 Dec 2011
Meister Stephan, Plouffe David M, Kuhen Kelli L, Bonamy Ghislain M C, Wu Tao, Barnes S Whitney, Bopp Selina E, Borboa Rachel, Bright A Taylor, Che Jianwei, Cohen Steve, Dharia Neekesh V, Gagaring Kerstin, Gettayacamin Montip, Gordon Perry, Groessl Todd, Kato Nobutaka, Lee Marcus C S, McNamara Case W, Fidock David A, Nagle Advait, Nam Tae-gyu, Richmond Wendy, Roland Jason, Rottmann Matthias, Zhou Bin, Froissard Patrick, Glynne Richard J, Mazier Dominique, Sattabongkot Jetsumon, Schultz Peter G, Tuntland Tove, Walker John R, Zhou Yingyao, Chatterjee Arnab, Diagana Thierry T, Winzeler Elizabeth A
Abstract excerpt
Most malaria drug development focuses on parasite stages detected in red blood cells, even though, to achieve eradication, next-generation drugs active against both erythrocytic and exo-erythrocytic forms would be preferable. We applied a multifactorial approach to a set of >4000 commercially available compounds with previously demonstrated blood-stage activity (median inhibitory concentration < 1 micromolar) and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.