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<i>Mtb</i> specific HLA-E restricted T cells are induced during <i>Mtb</i> infection but not after BCG administration in non-human primates and humans

2024-08-26

Abstract excerpt

Novel vaccines targeting the world’s deadliest pathogen Mycobacterium tuberculosis ( Mtb ) are urgently needed as the efficacy of the Bacillus Calmette–Guérin (BCG) vaccine in its current use is limited. HLA-E is a virtually monomorphic unconventional antigen presentation molecule and HLA-E restricted Mtb specific CD8 + T cells can control intracellular Mtb growth, making HLA-E a promising vaccine target for...

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Literature Corpus work
b7f02913-d063-5c71-b0ac-0b36d1ebfb41
DOI
10.1101/2024.08.26.609630
Open publication

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<i>Mtb</i> specific HLA-E restricted T cells are induced during <i>Mtb</i> infection but not after BCG administration in non-human primates and humansDOI 10.1101/2024.08.26.609630
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