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Article

HLA-E/Mtb specific CD4+ and CD8+ T cells have a memory phenotype in individuals with TB infection.

Frontiers in immunology - 1 Jan 2024

Voogd Linda, Riou Catherine, Scriba Thomas J, van Wolfswinkel Marjolein, van Meijgaarden Krista E, Franken Kees L M C, Wilkinson Robert J, Ottenhoff Tom H M, Joosten Simone A

Abstract excerpt

Introduction: Tuberculosis (TB) is the deadliest infectious disease worldwide and novel vaccines are urgently needed. HLA-E is a virtually monomorphic antigen presentation molecule and is not downregulated upon HIV co-infection. HLA-E restricted Mtb specific CD8+ T cells are present in the circulation of individuals with active TB (aTB) and Mtb infection (TBI) with or without HIV co-infection, making HLA-E...

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Share to CD4-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Histocompatibility Antigens Class I

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Source

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Identifiers

PMID: 39790998
DOI: 10.3389/fimmu.2024.1505329
PMCID: PMC11714851

Genes

CD4
KLRG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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