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Detailed characterization of human Mycobacterium tuberculosis specific HLA‐E restricted CD8+ T cells

10 Nov 2017

Abstract excerpt

Abstract HLA‐E presented antigens are interesting targets for vaccination given HLA‐Es’ essentially monomorphic nature. We have shown previously that Mycobacterium tuberculosis (Mtb) peptides are presented by HLA‐E to CD8+ effector T cells, but the precise phenotype and functional capacity of these cells remains poorly characterized. We have developed and utilized in this study a new protocol combining HLA‐E...

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PMID: 29124751
DOI: 10.1002/eji.201747184

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