Article

It takes a dimer to tango: Oligomeric small heat-shock proteins dissociate to capture substrate

2018-07-14

Abstract excerpt

Small heat-shock proteins (sHsps) are ubiquitous molecular chaperones, and their mutations or altered expression are linked to multiple human disease states. sHsp monomers assemble into large oligomers with dimeric substructure, and the dynamics of sHsp oligomers has led to major questions about the form that captures substrate, a critical aspect of their mechanism of action. We show that substructural dimers of p...

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Literature Corpus work: b7e3ade0-2aac-54c5-bcdf-3fdcf59b3c71
DOI: 10.1101/369454

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