Article
Multiple oligomeric structures of a bacterial small heat shock protein.
Scientific reports - 7 Apr 2016
Mani Nandini, Bhandari Spraha, Moreno Rodolfo, Hu Liya, Prasad B V Venkataram, Suguna Kaza
Abstract excerpt
Small heat shock proteins are ubiquitous molecular chaperones that form the first line of defence against the detrimental effects of cellular stress. Under conditions of stress they undergo drastic conformational rearrangements in order to bind to misfolded substrate proteins and prevent cellular protein aggregation. Owing to the dynamic nature of small heat shock protein oligomers, elucidating the structural...
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