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Dissecting the Functional Role of the N-Terminal Domain of the Human Small Heat Shock Protein HSPB6

26 Aug 2014

Abstract excerpt

HSPB6 is a member of the human small heat shock protein (sHSP) family, a conserved group of molecular chaperones that bind partially unfolded proteins and prevent them from aggregating. In vertebrate sHSPs the poorly structured N-terminal domain has been implicated in both chaperone activity and the formation of higher-order oligomers. These two functionally important properties are likely intertwined at the...

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PMID: 25157403
DOI: 10.1371/journal.pone.0105892

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