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Article

Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding.

Nature communications - 30 Nov 2016

Ungelenk Sophia, Moayed Fatemeh, Ho Chi-Ting, Grousl Tomas, Scharf Annette, Mashaghi Alireza, Tans Sander, Mayer Matthias P, Mogk Axel, Bukau Bernd

Abstract excerpt

Small heat shock proteins (sHsp) constitute an evolutionary conserved yet diverse family of chaperones acting as first line of defence against proteotoxic stress. sHsps coaggregate with misfolded proteins but the molecular basis and functional implications of these interactions, as well as potential sHsp specific differences, are poorly explored. In a comparative analysis of the two yeast sHsps, Hsp26 and Hsp42,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27901028
DOI: 10.1038/ncomms13673
PMCID: PMC5141385

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