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Article

Substrate binding site flexibility of the small heat shock protein molecular chaperones.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2009

Jaya Nomalie, Garcia Victor, Vierling Elizabeth

Abstract excerpt

Small heat shock proteins (sHSPs) serve as a first line of defense against stress-induced cell damage by binding and maintaining denaturing proteins in a folding-competent state. In contrast to the well-defined substrate binding regions of ATP-dependent chaperones, interactions between sHSPs and substrates are poorly understood. Defining substrate-binding sites of sHSPs is key to understanding their cellular...

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Identifiers

PMID: 19717454
DOI: 10.1073/pnas.0902177106
PMCID: PMC2773522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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