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INVESTIGATION OF ETHYLENE OXIDE GENOTOXICITY DOSE-RESPONSE TO INFORM CANCER RISK ASSESSMENT

2026-03-27

Abstract excerpt

<h4>ABSTRACT</h4> Ethylene oxide (EtO) is primarily used as an intermediate in the manufacture of chemicals, with a minor use as a sterilant for medical equipment and food products. It is a direct-acting alkylating agent that reacts with cellular macromolecules, including proteins and DNA. EtO has been shown to induce tumors in rodents and humans. DNA reactivity has been the postulated mode of action (MOA) for it...

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Literature Corpus work: dd7427c0-4846-5136-b959-8e01afe5d810
DOI: 10.64898/2026.03.25.714257

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