Article
Biomarkers of exposure and effect as indicators of potential carcinogenic risk arising from in vivo metabolism of ethylene to ethylene oxide.
Carcinogenesis - 1 Sept 2000
Walker V E, Wu K Y, Upton P B, Ranasinghe A, Scheller N, Cho M H, Vergnes J S, Skopek T R, Swenberg J A
Abstract excerpt
The purposes of the present study were: (i) to investigate the potential use of several biomarkers as quantitative indicators of the in vivo conversion of ethylene (ET) to ethylene oxide (EO); (ii) to produce molecular dosimetry data that might improve assessment of human risk from exogenous ET exposures. Groups (n = 7/group) of male F344 rats and B6C3F1 mice were exposed by inhalation to 0 and 3000 p. p.m. ET...
Topics
- Animals
- Biomarkers
- Biotransformation
- Carcinogens
- DNA
- DNA Damage
- Dose-Response Relationship, Drug
- Ethylene Oxide
- Ethylenes
- Guanine
- Hemoglobins
- Hypoxanthine Phosphoribosyltransferase
- Inhalation Exposure