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Article

Genotoxicity as a toxicologically relevant endpoint to inform risk assessment: A case study with ethylene oxide.

Environmental and molecular mutagenesis - 1 Nov 2020

Gollapudi Bala Bhaskar, Su Steave, Li Abby A, Johnson George E, Reiss Richard, Albertini Richard J

Abstract excerpt

The purpose of the present investigation is to analyze the in vivo genotoxicity dose-response data of ethylene oxide (EO) and the applicability of the derived point-of-departure (PoD) values when estimating permitted daily exposure (PDE) values. A total of 40 data sets were identified from the literature, and benchmark dose analyses were conducted using PROAST software to identify a PoD value. Studies employing...

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Identifiers

PMID: 32926486
DOI: 10.1002/em.22408
PMCID: PMC7756744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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