Article

PKCβ facilitates leukemogenesis in chronic lymphocytic leukaemia by promoting constitutive BCR-mediated signaling

2022-09-04

Abstract excerpt

B cell antigen receptor (BCR) signaling competence is critical for pathogenesis of chronic lymphocytic leukemia (CLL). Defining key proteins that facilitate these networks aid in the identification of targets for therapeutic exploitation. We previously demonstrated that reduced PKCα function in mouse hematopoietic stem/progenitor cells (HPSCs) resulted in PKCβII upregulation and generation of a poor-prognostic CLL...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b79ed9ba-a03f-5635-affd-1c57bf162e7e
DOI: 10.1101/2022.09.04.506520

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PKCβ facilitates leukemogenesis in chronic lymphocytic leukaemia by promoting constitutive BCR-mediated signalingDOI 10.1101/2022.09.04.506520Read

PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia.Semantic proximity Read

The B-cell receptor signaling pathway as a therapeutic target in CLLSemantic proximity Read

Regulation of protein kinase CbetaII (PKCbetaII) gene expression in chronic lymphocytic leukaemia (CLL) cellsSemantic proximity Read

Protein Kinase C Alpha is a Central Node for Tumorigenic Transcriptional Networks in Human Prostate CancerSemantic proximity Read

Protein Kinase C Alpha is a Central Node for Tumorigenic Transcriptional Networks in Human Prostate CancerSemantic proximity Read

Generation of Eμ-PKCβII transgenic mice for the study of chronic lymphocytic leukaemia (CLL)Semantic proximity Read

B cell signalling pathways—New targets for precision medicine in chronic lymphocytic leukaemiaSemantic proximity Read

Targeting ATM-deficient CLL through interference with DNA repair pathwaysSemantic proximity Read

PKCα as a signaling gatekeeper upstream of mTORC1 in mEGFR NSCLC.Semantic proximity Read

Protein Kinase C at the Crossroad of Mutations, Cancer, Targeted Therapy and Immune ResponseSemantic proximity Read

The complexities of PKCα signaling in cancer.Semantic proximity Read

PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes.Semantic proximity Read