Article

Protein Kinase C Alpha is a Central Node for Tumorigenic Transcriptional Networks in Human Prostate Cancer

2022-04-10

Abstract excerpt

<h4>ABSTRACT</h4> Aberrant expression of protein kinase C (PKC) isozymes is a hallmark of cancer. The different members of the PKC family control cellular events associated with cancer development and progression. Whereas the classical/conventional PKCα isozyme has been linked to tumor suppression in most cancer types, here we demonstrate that this kinase is required for the mitogenic activity of aggressive human...

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Literature Corpus work: dd6cfe98-fd09-5e1e-9556-aa295ba464f4
DOI: 10.1101/2022.04.08.487680

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